Health

What To Expect at Your First Ketamine Infusion

Starting ketamine therapy can feel like uncharted territory, especially for those dealing with treatment-resistant mental health conditions. While the potential for rapid symptom relief is promising, knowing what to expect at your first appointment helps eliminate uncertainty and ensures a more relaxed, informed experience. Patients preparing for ketamine infusion in Maryland often have similar questions surrounding preparation, side effects, and post-session logistics.   

Initial Assessment and Preparation

Before the infusion begins, a licensed healthcare provider will conduct a comprehensive evaluation. This includes reviewing your mental health history, medication use, and current symptoms. The goal is to determine whether ketamine is a safe and appropriate treatment path for your condition.

Once cleared, you’ll receive pre-infusion instructions. These typically involve fasting for several hours, arranging transportation, and avoiding certain medications. Comfort is a priority, so patients are often encouraged to wear loose clothing and bring items like music or an eye mask to help them relax during the session.

The Infusion Process

Ketamine infusions are administered intravenously in a medically supervised environment. The treatment typically lasts 40 to 60 minutes, during which you’ll be seated or reclining in a comfortable chair. A nurse or clinician will monitor your vitals throughout the session.

The effects of ketamine begin gradually. Many patients describe feelings of lightness, mild dissociation, or a dream-like state. These effects are expected and usually resolve shortly after the infusion ends. While each experience is unique, the environment is designed to promote safety and tranquility during this altered state of awareness.

Post-Infusion Expectations

After your infusion, you’ll remain under observation for 30 to 60 minutes. This ensures that side effects such as dizziness, nausea, or temporary disorientation subside before discharge. While the treatment can improve symptoms rapidly, the results are cumulative. Most protocols involve multiple infusions over several weeks to achieve full therapeutic benefit.

Because of the short-term cognitive and motor effects of ketamine, patients are advised not to operate a vehicle after treatment. In fact, when you can drive after a ketamine infusion is a common concern. Generally, patients should wait until the next day before driving or engaging in complex activities. This makes arranging a ride home or having someone accompany you an important part of pre-treatment planning.

Follow-Up and Ongoing Care

Most treatment plans involve ongoing assessments to monitor symptom changes, side effects, and mood improvements. Providers may adjust infusion frequency or explore additional therapies based on your response. Open communication with your care team is essential for long-term success.

Some patients experience immediate relief from symptoms such as anxiety or depression, while others may notice improvements after the second or third infusion. It’s critical to follow the prescribed schedule and maintain realistic expectations about how quickly results may appear.

Conclusion

A first ketamine infusion is a structured, medically supervised process designed to deliver therapeutic benefits with safety and care. By understanding what to expect, before, during, and after the session, patients can approach treatment with confidence and clarity. From initial screening to post-infusion monitoring, every step is tailored to support a positive and effective outcome.

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